US Patent Issued to Zevra Denmark on March 17 for "Use of HSP70 as a regulator of enzymatic activity" (Danish Inventors)

ALEXANDRIA, Va., March 17 -- United States Patent no. 12,576,076, issued on March 17, was assigned to Zevra Denmark A/S (Copenhagen N, Denmark).

"Use of HSP70 as a regulator of enzymatic activity" was invented by Thomas Kirkegaard Jensen (Rodovre, Denmark) and Marja H. Jaattela (Copenhagen O, Denmark).

According to the abstract* released by the U.S. Patent & Trademark Office: "Lysosomal membrane permeabilization is an evolutionarily conserved hallmark of stress-induced cell death. Here the inventors show that the major stress-inducible heat shock protein 70 (Hsp70) enhances cell survival by stabilizing lysosomes through a pH-dependent high affinity binding to an endo-lysosomal anionic phospholipid bis(monoacylglycero)phosphate (BMP; also ...