US Patent Issued to Yamasa on June 9 for "Practical enzymatic synthesis of 3',3'-cGAMP" (Japanese Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,649,941, issued on June 9, was assigned to Yamasa Corp. (Choshi, Japan).

"Practical enzymatic synthesis of 3',3'-cGAMP" was invented by Ko Yoshida (Choshi, Japan) and Kazuya Ishige (Choshi, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "In an enzymatic synthesis of 3',3'-cGAMP, other types of cyclic dinucleotides, c-di-GMP and c-di-AMP, are produced as by-products. One problem to be solved in order to establish a practical method for enzymatic synthesis of 3',3'-cGAMP is suppression of production of these other types of cyclic dinucleotides during the synthesis. As a result of intensive studies, the inventors of the present invention found a variat...