US Patent Issued to Yale University on Aug. 18 for "Targeting gene amplification in cancer using triplex formation as a therapeutic strategy" (Connecticut Inventor)

ALEXANDRIA, Va., Aug. 18 -- United States Patent no. 12,709,645, issued on Aug. 18, was assigned to Yale University (New Haven, Conn.).

"Targeting gene amplification in cancer using triplex formation as a therapeutic strategy" was invented by Faye A. Rogers (Norwalk, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are methods and agents for the treatment of cancer using p53-independent apoptosis to reduce the number of p53-depleted or p53-mutated cancer cells that have amplified HER2 gene. Also disclosed herein are methods and agents for the treatment of HER2-positive cancer in individuals with Li-Fraumeni Syndrome."

The patent was filed on June 27, 2022, under Application No. 17/850,7...