ALEXANDRIA, Va., July 28 -- United States Patent no. 12,691,089, issued on July 28, was assigned to Xeris Pharmaceuticals Inc. (Chicago).
"Stable levothyroxine compositions in aprotic polar solvents" was invented by Martin Donovan (El Paso, Texas), Wendy Hu (San Diego), Richard Fitch (Chicago) and Steven Prestrelski (San Diego).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention concerns the use of aprotic polar solvents and an ionization stabilizing agent to prepare stable therapeutic formulations of levothyroxine by dissolving levothyroxine in an aprotic polar solvent system that can then be used to treat, prevent, and/or diagnose certain diseases and disorders in humans and veterinary anim...