US Patent Issued to Wisconsin Alumni Research Foundation on Sept. 15 for "Generation of uniform hepatocytes from human embryonic stem cells by inhibiting TGF-beta and methods of maintaining hepatic cultures" (Wisconsin Inventors)

ALEXANDRIA, Va., Sept. 15 -- United States Patent no. 12,734,197, issued on Sept. 15, was assigned to Wisconsin Alumni Research Foundation (Madison, Wis.).

"Generation of uniform hepatocytes from human embryonic stem cells by inhibiting TGF-beta and methods of maintaining hepatic cultures" was invented by James A. Thomson (Madison, Wis.) and Srikumar Sengupta (Madison, Wis.).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure relates generally to new methods of maintaining the expression of hepatic genes in human hepatocytes and method for maintaining the functional hepatic enzyme activity of primary hepatocytes in culture. The disclosure also encompasses new methods of deriving a population of pur...