US Patent Issued to Wisconsin Alumni Research Foundation on Oct. 20 for "Chemical cocktail for inducing senescence in human neurons to promote disease modeling and drug discovery" (Wisconsin Inventors)

ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,768,832, issued on Oct. 20, was assigned to Wisconsin Alumni Research Foundation (Madison, Wis.).

"Chemical cocktail for inducing senescence in human neurons to promote disease modeling and drug discovery" was invented by Su-Chun Zhang (Waunakee, Wis.) and Ali Fathi (Madison, Wis.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are methods and compositions for inducing chemical senescence in neurons and methods of using chemically induced senescent neurons for modeling neurodegenerative disease and drug discovery. The methods include contacting human neurons with a culture medium comprising an inhibitor of DNA glycosylase 1, an autophagy ...