US Patent Issued to Wisconsin Alumni Research Foundation on Aug. 4 for "Engineered tryptophan decarboxylases and uses thereof for synthesizing tryptamine analogs" (American, German Inventors)

ALEXANDRIA, Va., Aug. 5 -- United States Patent no. 12,698,495, issued on Aug. 4, was assigned to Wisconsin Alumni Research Foundation (Madison, Wis.).

"Engineered tryptophan decarboxylases and uses thereof for synthesizing tryptamine analogs" was invented by Andrew Buller (Madison, Wis.) and Allwin McDonald (Jena, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "Unnatural, mutant tryptophan decarboxylase proteins and methods of using same. The mutants have an amino acid sequence at least 80% identical to SEQ ID NO:1 and have substitutions at one or more of amino acid positions 98, 99, 120, 126, 339, 349, and 355 of SEQ ID NO:1. The mutants can have enhanced activity and/or substrate promiscuity and be...