ALEXANDRIA, Va., April 15 -- United States Patent no. 12,601,004, issued on April 14, was assigned to Watchmaker Genomics Inc. (Boulder, Colo.).
"Depletion probes" was invented by Travis J. Sanders (Boulder, Colo.), Martin Ranik (Boulder, Colo.) and Brian A. Kudlow (Boulder, Colo.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides sets of RNA depletion probes, short DNA oligos that hybridize along the length of a target RNA and mediate digestion of the target RNA by RNase H to remove super-abundant RNA molecules from a sample. Depletion probes according to the invention are designed foremost based on biochemistry and the biophysical properties of the probes so that all of the depletion pro...