ALEXANDRIA, Va., March 24 -- United States Patent no. 12,582,703, issued on March 24, was assigned to VirTech Bio Inc. (Natick, Mass.).

"Blood substitutes comprising hemoglobin and methods of making" was invented by William Richard Light (Natik, Mass.) and Joseph Tucker (Natick, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Methods for making hemoglobin based blood substitute preparations and hemoglobin based blood substitute preparations. The methods involve preparing a low purity erythrocyte protein fraction comprising hemoglobin protein and endogenous non-hemoglobin protein complement, and chemically modifying the proteins in the protein fraction to form a cross-linked hemoglobin containing blood s...