US Patent Issued to Verve Therapeutics on June 9 for "Chemically modified guide RNAs for genome editing with Cas12b" (Massachusetts Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,649,921, issued on June 9, was assigned to Verve Therapeutics Inc. (Boston).

"Chemically modified guide RNAs for genome editing with Cas12b" was invented by Kallanthottathil G. Rajeev (Wayland, Mass.), Alexandra Chadwick (Somerville, Mass.) and Caroline Reiss (Somerville, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are compositions related to Cas12b guide RNAs. Also provided herein are methods for modifying target polynucleotide sequences and methods of treating or preventing a condition in a subject in need thereof, such as conditions resultant from the expression of ANGPTL3 or mutations thereto."

The patent was filed on April ...