ALEXANDRIA, Va., March 17 -- United States Patent no. 12,577,258, issued on March 17, was assigned to VERNALIS (R&D) Ltd. (Great Abington, Great Britain) and ASAHI KASEI PHARMA Corp. (Tokyo).

"Macrocyclic compound" was invented by Takahiko Ito (Tokyo), Misato Takashima (Tokyo), Masakazu Atobe (Tokyo), Koichiro Arai (Tokyo), Tomohisa Toyama (Tokyo), Yu Yoshii (Tokyo), Andrew John Potter (Great Abington, Great Britain), Daniel Paul Maddox (Great Abington, Great Britain), Stuart Ray (Great Abington, Great Britain) and Nicolas Foloppe (Great Abington, Great Britain).

According to the abstract* released by the U.S. Patent & Trademark Office: "A compound represented by the general formula (1) or a salt thereof, which has a superior IRAK-4 inhib...