US Patent Issued to Vanderbilt University on Aug. 4 for "Lymphocytes lacking perforin function" (Tennessee Inventors)

ALEXANDRIA, Va., Aug. 5 -- United States Patent no. 12,698,475, issued on Aug. 4, was assigned to Vanderbilt University (Nashville, Tenn.).

"Lymphocytes lacking perforin function" was invented by Richard T. O'Neil (Nashville, Tenn.) and Matthew H. Wilson (Nashville, Tenn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are engineered cell-based peptide delivery platforms based on T cells lacking Perforin function. Perforin-null T cells lack cytotoxic effector function and thus are not capable of killing target cells by conventional Perforin dependent pathways. However, they efficiently home to target tissues where they can invade, persist, and proliferate. The homing ability of perforin lacki...