US Patent Issued to VANDERBILT UNIVERSITY on Aug. 25 for "Quinazoline-4(3H)-one derivatives as negative allosteric modulators of metabotropic glutamate receptor 2" (Tennessee Inventors)

ALEXANDRIA, Va., Aug. 25 -- United States Patent no. 12,715,879, issued on Aug. 25, was assigned to VANDERBILT UNIVERSITY (Nashville, Tenn.).

"Quinazoline-4(3H)-one derivatives as negative allosteric modulators of metabotropic glutamate receptor 2" was invented by Elizabeth S. Childress (Nashville, Tenn.) and Craig W. Lindsley (Brentwood, Tenn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described are 6-aryl quinazolin-4(3H)-ones as negative allosteric modulators of metabotropic glutamate receptor 2 (mGlu2), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating depression, anxiety, obsessive-compulsive disorder, cognitive disorders, Alzheimer...