US Patent Issued to University of Southern California on Feb. 17 for "Androgen receptor regulation by small molecule enantiomers" (California Inventors)

ALEXANDRIA, Va., Feb. 17 -- United States Patent no. 12,552,806, issued on Feb. 17, was assigned to University of Southern California (Los Angeles).

"Androgen receptor regulation by small molecule enantiomers" was invented by Charles E. McKenna (Los Angeles) and David B. Agus (Los Angeles).

According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported a class of chiral compounds with paradoxical effects on the androgen receptor (AR). The (R)-enantiomers behave like classical anti-androgens while the (S)-enantiomers activate AR signaling. In castration-resistant prostate cancer, the change during the course of therapy to growth in the presence of AR targeted therapeutics, a harbinger of progression to letha...