US Patent Issued to University of Pittsburgh-Of the Commonwealth System of Higher Education on May 19 for "One-step gene therapy for Duchenne muscular dystrophy via gene replacement and anti-inflammation" (Pennsylvania Inventors)

ALEXANDRIA, Va., May 19 -- United States Patent no. 12,630,840, issued on May 19, was assigned to University of Pittsburgh-Of the Commonwealth System of Higher Education (Pittsburgh).

"One-step gene therapy for Duchenne muscular dystrophy via gene replacement and anti-inflammation" was invented by Bing Wang (Cheswick, Pa.) and Freddie Fu (Pittsburgh).

According to the abstract* released by the U.S. Patent & Trademark Office: "In one embodiment, the invention provides a dual-cassette gene vehicle comprising cassettes for expression of both a mini-dystrophin gene and NF-KappaB/p65-shRNA gene in cardiac muscle tissue and skeletal muscle tissue, which is an adeno-associated viral (AAV) vector, wherein the mini-dystrophin gene is operably link...