ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,461, issued on Feb. 24, was assigned to UNIVERSITY OF NOTRE DAME DU LAC (South Bend, Ind.).
"Antibiotic adjuvant compounds" was invented by Christian Melander (South Bend, Ind.) and Veronica Hubble (South Bend, Ind.).
According to the abstract* released by the U.S. Patent & Trademark Office: "We report improved adjuvant compounds that have an aryl 2-aminoimidazole structure for macrolide potentiation against a virulent strain of gram-negative bacteria, AB5075. Compounds were discovered to retain significant adjuvant activity at 10 MuM, lowering the minimum inhibitory concentration (MIC) of clarithromycin (CLR) from 8-fold to 128-fold or greater. 2-Aminoimidazole compounds linked ...