US Patent Issued to University of Notre Dame du Lac on Aug. 4 for "Antibacterial picolinamide compounds" (Indiana Inventors)

ALEXANDRIA, Va., Aug. 5 -- United States Patent no. 12,698,276, issued on Aug. 4, was assigned to University of Notre Dame du Lac (South Bend, Ind.).

"Antibacterial picolinamide compounds" was invented by Shahriar Mobashery (South Bend, Ind.), Mayland Chang (South Bend, Ind.) and Enrico Speri (South Bend, Ind.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Here we report the discovery of 2-(4-(3-(trifluoromethoxy)phenoxy)picolinamido)benzo[d]oxazole-5-carboxylate as an antibacterial with potent and selective activity against C. difficile. Its MIC50 and MIC90 values, documented across 101 strains of C. difficile, are 0.12 and 0.25 Mug/mL, respectively. The compound is effective against C. difficile both at th...