US Patent Issued to University of Massachusetts on Sept. 29 for "DCAS13-mediated therapeutic RNA base editing for in vivo gene therapy" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,746,295, issued on Sept. 29, was assigned to University of Massachusetts (Westborough, Mass.).

"DCAS13-mediated therapeutic RNA base editing for in vivo gene therapy" was invented by Dan Wang (Worcester, Mass.), Guangping Gao (Worcester, Mass.) and Jiaming Wang (Worcester, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Aspects of the disclosure relate to compositions (e.g., isolated nucleic acids, rAAV vectors, rAAVs, etc.) and methods for gene editing. The disclosure is based, in part, on isolated nucleic acids encoding combinations of gene editing proteins (e.g., Cas proteins) and base editors (e.g., Adenosine Deaminase Acting on RNA deaminase ...