US Patent Issued to UNIVERSITY OF MASSACHUSETTS on Oct. 6 for "Prime editor system for in vivo genome editing" (Massachusetts Inventors)

ALEXANDRIA, Va., Oct. 6 -- United States Patent no. 12,753,397, issued on Oct. 6, was assigned to UNIVERSITY OF MASSACHUSETTS (Westborough, Mass.).

"Prime editor system for in vivo genome editing" was invented by Shun-Qing Liang (Shrewsbury, Mass.), Pengpeng Liu (Worcester, Mass.), Wen Xue (Natick, Mass.) and Scot Wolfe (Winchester, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present applications discloses an NLS-optimized SpCas9-based prime editor that improves genome editing efficiency exemplified by endogenous loci in cultured cell lines. Using this genome modification system, tumor formation can be initiated through somatic cell editing in the adult mouse. Furthermore, a dual adeno-associate...