US Patent Issued to University of Massachusetts on March 24 for "DNA-binding domain transactivators and uses thereof" (Massachusetts Inventors)

ALEXANDRIA, Va., March 24 -- United States Patent no. 12,583,902, issued on March 24, was assigned to University of Massachusetts (Westborough, Mass.).

"DNA-binding domain transactivators and uses thereof" was invented by Miguel Sena Esteves (Worcester, Mass.) and Scot A. Wolfe (Worcester, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "In some aspects, the disclosure relates to recombinant adeno-associated viruses (rAAVs) comprising a nucleic acid encoding a fusion protein comprising a DNA-binding domain and a transcriptional regulator domain and methods of using the same. In some embodiments, expression of the fusion protein results in modified expression of a target gene in a cell."

The patent was f...