US Patent Issued to University of Massachusetts on Feb. 17 for "CAS13 family AAV vectors and uses thereof" (Massachusetts Inventors)

ALEXANDRIA, Va., Feb. 17 -- United States Patent no. 12,553,063, issued on Feb. 17, was assigned to University of Massachusetts (Westborough, Mass.).

"CAS13 family AAV vectors and uses thereof" was invented by Guangping Gao (Worcester, Mass.) and Alexander Brown (Worcester, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Aspects of the disclosure relate to compositions and methods for multiplexed gene silencing in a cell or subject. In some embodiments, the disclosure provides an isolated nucleic acid or an rAAV encoding a transgene comprising a RNA-guided nuclease (RGN) operably linked to a first promoter, and a second promoter operably linked to a multi guide-RNA (multi-gRNA) expression cassette encod...