US Patent Issued to University of Louisville Research Foundation on March 24 for "Inhibitors of the RAS oncoprotein, methods of making and methods of use thereof" (Kentucky Inventors)

ALEXANDRIA, Va., March 24 -- United States Patent no. 12,582,660, issued on March 24, was assigned to University of Louisville Research Foundation Inc. (Louisville, Ky.).

"Inhibitors of the RAS oncoprotein, methods of making and methods of use thereof" was invented by Geoffrey J. Clark (Pewee Valley, Ky.), John O. Trent (Louisville, Ky.) and Joseph A. Burlison (Louisville, Ky.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A compound for use in treating a disease associated with activating mutations in RAS, or for use in treating a disease treatable by a reduction in RAS activity, is selected from a compound of Formula (I), salts and esters thereof. The compounds are particularly useful in treating cancer."...