US Patent Issued to UNIVERSITY OF IOWA RESEARCH FOUNDATION on March 3 for "Methods of rescuing stop codons via genetic reassignment with ACE-tRNA" (Iowa Inventors)

ALEXANDRIA, Va., March 3 -- United States Patent no. 12,565,649, issued on March 3, was assigned to UNIVERSITY OF IOWA RESEARCH FOUNDATION (Iowa City, Iowa).

"Methods of rescuing stop codons via genetic reassignment with ACE-tRNA" was invented by Christopher Ahern (Iowa City, Iowa) and John D. Lueck (Iowa City, Iowa).

According to the abstract* released by the U.S. Patent & Trademark Office: "In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, an anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof. In certain embodiments, the present invention provides a modified transfe...