US Patent Issued to University of Florida Research Foundation on May 19 for "AAV capsid variants for targeting human glioblastoma cells" (Florida Inventors)

ALEXANDRIA, Va., May 19 -- United States Patent no. 12,630,845, issued on May 19, was assigned to University of Florida Research Foundation Inc. (Gainesville, Fla.).

"AAV capsid variants for targeting human glioblastoma cells" was invented by Sergei Zolotukhin (Gainesville, Fla.), David Tran (Gainesville, Fla.) and Oleksandr Kondratov (Gainesville, Fla.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are AAV particles having capsid proteins with amino acid substitutions that confer increased affinity for and transduction of glioma cells. The disclosed capsid proteins may be used in conjunction with any therapeutic transgene for treatment of cancer, including in the manufacture of an AAV parti...