US Patent Issued to University Health Network on May 12 for "T cell receptors and methods of use thereof" (Canadian Inventors)

ALEXANDRIA, Va., May 12 -- United States Patent no. 12,624,082, issued on May 12, was assigned to University Health Network (Toronto).

"T cell receptors and methods of use thereof" was invented by Naoto Hirano (Toronto), Kenji Sugata (Toronto) and Kayoko Saso (Toronto).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure is directed recombinant T cell receptors capable of binding a MUC5AC epitope and nucleic acid molecules encoding the same. In some aspects, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence or the polypeptide encoded by the second nucleotide sequence inhibits the expression of an endogenous TCR. Other aspects of t...