US Patent Issued to TSINGHUA UNIVERSITY on July 7 for "Development of dual-gRNA approach with undetectable off-target effect to correct C9ORF72 repeat expansion and C9ORF72 pathology" (Chinese Inventors)

ALEXANDRIA, Va., July 7 -- United States Patent no. 12,673,118, issued on July 7, was assigned to TSINGHUA UNIVERSITY (Beijing).

"Development of dual-gRNA approach with undetectable off-target effect to correct C9ORF72 repeat expansion and C9ORF72 pathology" was invented by Xuejiao Piao (Beijing) and Yichang Jia (Beijing).

According to the abstract* released by the U.S. Patent & Trademark Office: "A group of gRNAs is provided, and the group of gRNAs comprises a first gRNA molecule; and a second gRNA molecule capable of defining a region in a genome sequence with the first gRNA molecule, wherein the region in the genome comprises a target sequence in need of removal."

The patent was filed on Dec. 23, 2019, under Application No. 17/788,670...