ALEXANDRIA, Va., May 26 -- United States Patent no. 12,637,493, issued on May 26, was assigned to Trustees of Boston University (Boston).
"Engineered MCP and PCP proteins and systems and methods thereof" was invented by John T. Ngo (Boston), Christopher Joseph Kuffner (Boston) and Alex Marzilli (Boston).
According to the abstract* released by the U.S. Patent & Trademark Office: "The technology described herein is directed to engineered MCP proteins and engineered PCP proteins, which are degraded when the proteins are not bound to an MS2 or PP7 RNA hairpin loop, respectively. Also described herein are fusion proteins comprising such engineered MCP proteins and engineered PCP proteins linked to various effector proteins. The linkage to the ...