US Patent Issued to TRITERPENOID THERAPEUTICS on Feb. 17 for "Methods and compositions for irreversible enzyme inhibition" (New Hampshire, Vermont Inventors)

ALEXANDRIA, Va., Feb. 17 -- United States Patent no. 12,551,562, issued on Feb. 17, was assigned to TRITERPENOID THERAPEUTICS INC. (Lebanon, N.H.).

"Methods and compositions for irreversible enzyme inhibition" was invented by Michael B. Sporn (Tunbridge, Vt.) and Xiaoli Meng (Lebanon, N.H.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to compounds, methods, and compositions for irreversibly inhibiting protein targets, including Keap1 and/or LONP1 protease. In certain aspects, the present invention relates to conjugates and/or cross-linked conjugates comprising a protein or a protein complex and a bifunctional triterpenoid, such as 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl...