US Patent Issued to TRIANNI on Aug. 25 for "Single chain VH and heavy chain antibodies" (American, German Inventors)

ALEXANDRIA, Va., Aug. 25 -- United States Patent no. 12,715,906, issued on Aug. 25, was assigned to TRIANNI INC. (San Francisco).

"Single chain VH and heavy chain antibodies" was invented by Werner Mueller (Cologne, Germany) and Matthias Wabl (San Francisco).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides cells, transgenic animals, including transgenic mammals and particularly rodents comprising engineered immunoglobulin (Ig) alleles. Such engineered alleles, wherein an Ig light chain CL exon [CKappa or CLambda (CLambda1, CLambda2 or CLambda3)] is incorporated into the Ig heavy chain locus, are capable of producing heavy chain-only antibodies as a single chain VH antibody (scVHAb...