ALEXANDRIA, Va., April 7 -- United States Patent no. 12,595,258, issued on April 7, was assigned to Tolremo Therapeutics AG (Muttenz, Switzerland).

"Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer" was invented by Charles-Henry Fabritius (Muttenz, Switzerland), Koen Hekking (Muttenz, Switzerland), Dorothea Gruber (Muttenz, Switzerland), Rutger Folmer (Muttenz, Switzerland), Stefanie Fluckiger-Mangual (Muttenz, Switzerland), Thomas Bohnacker (Muttenz, Switzerland), Martin Schwill (Muttenz, Switzerland) and Debora Schmitz-Rohmer (Muttenz, Switzerland).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to compounds of formul...