ALEXANDRIA, Va., Sept. 8 -- United States Patent no. 12,729,396, issued on Sept. 8, was assigned to Thermo Finnigan LLC (San Jose, Calif.).
"Method for quantitative monitoring mRNA capping efficiency" was invented by Robert L. Ross (Hopkinton, Mass.) and Min Du (Acton, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "A method for quantifying mRNA capping efficiency includes combining a sample, an enzyme mixture, and an isotopic standard solution in a buffer solution to create an incubation mixture, the enzyme mixture including a non-specific, single-stranded nuclease and an acid phosphatase and the isotopic standard including isotopically labeled m7G and isotopically labeled 2'-O-methylated nucleoside; i...