US Patent Issued to The University of Hong Kong, Children's Hospital Medical Center on April 14 for "Innervated organoid compositions and methods of making same" (Chinese, American Inventors)

ALEXANDRIA, Va., April 15 -- United States Patent no. 12,600,943, issued on April 14, was assigned to The University of Hong Kong and Children's Hospital Medical Center (Cincinnati).

"Innervated organoid compositions and methods of making same" was invented by Sau-Wai Elly Ngan (Hong Kong, Hong Kong) and James M. Wells (Cincinnati).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are in vitro methods for the differentiation of precursor cells into a neural crest cell (NCC) primed to a neurogenic lineage. The methods may include, for example, the steps of activating a Hedgehog signaling pathway ("HH signaling pathway") in a precursor cell, wherein the precursor cell may be contacted with a neural crest...