US Patent Issued to The United States of America, as represented by the Secretary, Department of Health and Human Services on Sept. 1 for "T cell receptors recognizing R273C or Y220C mutations in P53" (Maryland Inventors)

ALEXANDRIA, Va., Sept. 1 -- United States Patent no. 12,721,890, issued on Sept. 1, was assigned to The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Md.).

"T cell receptors recognizing R273C or Y220C mutations in P53" was invented by Sanghyun Kim (Rockville, Md.), Nikolaos Zacharakis (Gaithersburg, Md.) and Steven A. Rosenberg (Potomac, Md.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are isolated or purified T cell receptors (TCRs) having antigenic specificity for human p53R273C or human p53Y220C. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, a...