US Patent Issued to The United States of America, as represented by the Secretary, Department of Health and Human Services, Shenzhen Xuhua Biotech on June 16 for "Oxynitidine derivatives useful as inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1)" (Chinese, American Inventors)

ALEXANDRIA, Va., June 16 -- United States Patent no. 12,655,107, issued on June 16, was assigned to The United States of America, as represented by the Secretary, Department of Health and Human Services (Bethesda, Md.) and Shenzhen Xuhua Biotech Co. Ltd. (Shenzhen, China).

"Oxynitidine derivatives useful as inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1)" was invented by Lin-Kun An (Guangzhou, China), Xiaoru Zhang (Guangzhou, China), Haowen Wang (Guangzhou, China), Yves Georges Pommier (Bethesda, Md.), Evgeny A. Kiselev (Rockville, Md.), Azhar Ali Ravji (Bethesda, Md.) and Keli Kisseh Agama (Bethesda, Md.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Compounds and pharmaceut...