US Patent Issued to The Trustees of the Unviersity of Pennsylvania, The United States of America as represented by the Department of Veterans Affairs on Feb. 24 for "Engineered expression of cell surface and secreted sialidase by CAR T cells for increased efficacy in solid tumors" (Pennsylvania Inventors)

ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,719, issued on Feb. 24, was assigned to The Trustees of the Unviersity of Pennsylvania (Philadelphia) and The United States of America as represented by the Department of Veterans Affairs (Washington).

"Engineered expression of cell surface and secreted sialidase by CAR T cells for increased efficacy in solid tumors" was invented by Avery D. Posey (Philadelphia) and Tiffany King (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides modified immune cells or precursors thereof (e.g. modified T cells) comprising a chimeric cell surface sialidase or a variant sialidase precursor protein. Compositions and methods of...