US Patent Issued to The Trustees of the University of Pennsylvania on Oct. 6 for "Dual CAR expressing T cells individually linked to CD28 and 4-1BB" (New Hampshire, Pennsylvania Inventors)

ALEXANDRIA, Va., Oct. 6 -- United States Patent no. 12,753,218, issued on Oct. 6, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Dual CAR expressing T cells individually linked to CD28 and 4-1BB" was invented by James L. Riley (Downingtown, Pa.) and Colby Maldini (Newington, N.H.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to modified immune cells or precursors thereof, comprising dual (a first and a second) chimeric receptors (e.g. CARs). One aspect includes a first CAR comprising a 4-1BB intracellular domain and a second CAR comprising a CD28 intracellular domain. Another aspect includes a method for treating of an HIV infected mammal using ...