US Patent Issued to The Trustees of the University of Pennsylvania on March 17 for "Altering gene expression in modified T cells and uses thereof" (Pennsylvania, New Jersey Inventors)

ALEXANDRIA, Va., March 17 -- United States Patent no. 12,577,567, issued on March 17, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Altering gene expression in modified T cells and uses thereof" was invented by Yangbing Zhao (Lumberton, N.J.), Jiangtao Ren (Philadelphia), Xiaojun Liu (Wallingford, Pa.) and Carl H. June (Merion Station, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR Alpha chain, TCR Beta chain, beta-2 microglobulin and FAS further comprising a nucleic a...