US Patent Issued to The Trustees of the University of Pennsylvania on Aug. 4 for "Identifying epigenetic and transcriptional targets to prevent and reverse T cell exhaustion" (Pennsylvania Inventors)

ALEXANDRIA, Va., Aug. 5 -- United States Patent no. 12,698,499, issued on Aug. 4, was assigned to The Trustees of the University of Pennsylvania (Philadelphia).

"Identifying epigenetic and transcriptional targets to prevent and reverse T cell exhaustion" was invented by E. John Wherry (Havertown, Pa.), Omar Khan (Philadelphia) and Martha Jordan (Wynnewood, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides methods of preventing, reversing or increasing T cell exhaustion in a patient having a disease. The present invention also provides methods for treating a disease in a patient having the disease. The present invention also provides an engineered T cell comprising a high prior...