US Patent Issued to The Trustees of the University of Pennsylvania, THE CHILDREN'S HOSPITAL OF PHILADELPHIA on May 26 for "In utero CRISPR-mediated therapeutic editing of genes" (Pennsylvania Inventors)

ALEXANDRIA, Va., May 26 -- United States Patent no. 12,636,381, issued on May 26, was assigned to The Trustees of the University of Pennsylvania (Philadelphia) and THE CHILDREN'S HOSPITAL OF PHILADELPHIA (Philadelphia).

"In utero CRISPR-mediated therapeutic editing of genes" was invented by Kiran Musunuru (Philadelphia), William H. Peranteau (Philadelphia) and Edward Morrisey (Newton Square, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method for in utero genome editing, the method comprising administering to a subject an adenoviral vector, wherein the subject is a fetus, the adenoviral vector comprising CRISPR-mediated base editor and a guide RNA (gRNA), the gRNA targeting a mutation in a therapeuti...