US Patent Issued to THE SCRIPPS RESEARCH INSTITUTE on Sept. 22 for "Tautomeric ligand enables biomimetic C-H hydroxylation with molecular oxygen" (California Inventors)

ALEXANDRIA, Va., Sept. 24 -- United States Patent no. 12,741,937, issued on Sept. 22, was assigned to THE SCRIPPS RESEARCH INSTITUTE (La Jolla, Calif.).

"Tautomeric ligand enables biomimetic C-H hydroxylation with molecular oxygen" was invented by Jin-Quan Yu (San Diego), Zhen Wang (San Diego) and Zhen Li (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein is a process for making a compound of formula (2) by (hetero)aromatic C-H hydroxylation of a compound of formula (1): catalyzed by palladium(II) and a bidentate ligand in the presence of O2. The process is useful for instance, in the late-stage modification of medicinally important heterocycles."

The patent was filed on Dec. 9, 2021...