US Patent Issued to The Rockefeller University on March 24 for "Compositions and methods to treat metastatic gastrointestinal cancer" (New York Inventors)

ALEXANDRIA, Va., March 24 -- United States Patent no. 12,582,667, issued on March 24, was assigned to The Rockefeller University (New York).

"Compositions and methods to treat metastatic gastrointestinal cancer" was invented by Sohail Tavazoie (New York), Norihiro Yamaguchi (New York) and Kivanc Birsoy (New York).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to agents and methods for treating gastrointestinal cancer (e.g., metastatic colorectal cancer) in a subject in need thereof. The method includes suppressing the enzymatic activity of DHODH and/or decreasing the level of creatine via suppression of creatine transporter channel SLC6a8 in the subject. In some embodiments, the ...