US Patent Issued to The Regents of the University of Michigan on May 19 for "Compositions and methods for T-cell and cytokine activation" (Michigan Inventor)

ALEXANDRIA, Va., May 19 -- United States Patent no. 12,630,641, issued on May 19, was assigned to The Regents of the University of Michigan (Ann Arbor, Mich.).

"Compositions and methods for T-cell and cytokine activation" was invented by Challice Bonifant (Ann Arbor, Mich.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Chimeric antigen receptors (CARs) are provided that comprise a CD123-specific antigen recognition domain and IL7Ra transmembrane and intracellular signaling domains (CD123/IL7Ra CARs). In particular embodiments, provided herein are engineered lymphocytes that express and display CD123/IL7Ra CARs, and methods of targeting CD123-positive leukemic cells and treating leukemias, such as acute myelo...