ALEXANDRIA, Va., Nov. 11 -- United States Patent no. 12,467,044, issued on Nov. 11, was assigned to The Regents of the University of California (Oakland, Calif.).
"Mutant aminoacyl tRNA synthetase" was invented by Lei Wang (San Francisco).
According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are novel materials and methods for site-specific incorporation of phosphotyrosines into proteins. The novel methods of the invention encompass the use of a novel aminoacyl tRNA synthetase capable of charging compatible tRNAs with a phosphotyrosine precursor. The phosphotyrosine precursor is then incorporated, site-specifically, into a protein at sites where phosphotyrosine residues are desired. The phosphotyrosi...