US Patent Issued to The Regents of the University of California on June 23 for "Humanized notch receptors with hinge domain" (California Inventors)

ALEXANDRIA, Va., July 15 -- United States Patent no. 12,662,675, issued on June 23, was assigned to The Regents of the University of California (Oakland, Calif.).

"Humanized notch receptors with hinge domain" was invented by Kole T. Roybal (San Francisco) and Raymond Liu (San Francisco).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure generally relates to, inter alia, a new class of chimeric Notch receptors containing a fully humanized transcriptional effector, engineered to modulate gene expression and cellular activities in a ligand-dependent manner. The new chimeric Notch receptors surprisingly retain the ability to transduce signals in response to ligand binding despite that the Notch...