US Patent Issued to The Regents of the University of California on June 23 for "Compounds and methods for inducing UCP1 expression" (California Inventors)

ALEXANDRIA, Va., July 15 -- United States Patent no. 12,661,355, issued on June 23, was assigned to The Regents of the University of California (Oakland, Calif.).

"Compounds and methods for inducing UCP1 expression" was invented by Laurent Vergnes (Oakland, Calif.) and Karen Reue (Oakland, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The compounds and methods of the present disclosure exhibit induce Ucp1 transcription, enhance of mitochondrial respiration, activate protein kinase A, increase lipolysis, and increase p38 MAPK phosphorylation in cells, particularly brown adipocytes and white adipocytes. They also protect primary cardiomyocytes against hypertrophy induced by adrenergic agonists. Such co...