US Patent Issued to The Regents of the University of California on Aug. 11 for "CRISPR-Cas9-inhibiting polypeptide" (California Inventors)

ALEXANDRIA, Va., Aug. 12 -- United States Patent no. 12,703,723, issued on Aug. 11, was assigned to The Regents of the University of California (Oakland, Calif.).

"CRISPR-Cas9-inhibiting polypeptide" was invented by Joseph Bondy-Denomy (Oakland, Calif.) and Benjamin Rauch (Oakland, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "CRISPR-Cas9-inhibiting polypeptides, cells expressing the polypeptides, and polynucleotides encoding the polypeptides are provided. The Cas9-inhibiting polypeptides can be used in many aspects to inhibit unwanted Cas9 activity. For example, one or more Cas9-inhibiting polypeptides can be used to regulate Cas9 in genome editing, thereby allowing for some Cas9 activity prior to i...