US Patent Issued to The Johns Hopkins University on March 3 for "Hybrid cyclic libraries and screens thereof" (American, Chinese Inventors)

ALEXANDRIA, Va., March 3 -- United States Patent no. 12,565,518, issued on March 3, was assigned to The Johns Hopkins University (Baltimore).

"Hybrid cyclic libraries and screens thereof" was invented by Jun O. Liu (Clarksville, Md.), Jingxin Wang (Baltimore), Zufeng Guo (Baltimore), Wei Li (Xiangtan, China), Shridhar Bhat (Cockeysville, Md.) and Manisha Das (Centreville, Md.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applica...