US Patent Issued to The General Hospital on April 21 for "Highly sensitive in vitro assays to define substrate preferences and sites of nucleic-acid binding, modifying, and cleaving agents" (Massachusetts Inventors)

ALEXANDRIA, Va., April 21 -- United States Patent no. 12,606,867, issued on April 21, was assigned to The General Hospital Corp. (Boston).

"Highly sensitive in vitro assays to define substrate preferences and sites of nucleic-acid binding, modifying, and cleaving agents" was invented by J. Keith Joung (Winchester, Mass.), Vikram Pattanayak (Wellesley, Mass.) and Karl Petri (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are, among other things, methods of identifying double stranded DNA sequences that are modified by a base editing enzyme. For example, by providing a plurality of linear dsDNA oligonucleotides of known sequences, incubating the library in the presence of a ba...