US Patent Issued to The General Hospital on April 14 for "Highly sensitive in vitro assays to define substrate preferences and sites of nucleic-acid binding, modifying, and cleaving agents" (Massachusetts Inventors)

ALEXANDRIA, Va., April 15 -- United States Patent no. 12,601,009, issued on April 14, was assigned to The General Hospital Corp. (Boston).

"Highly sensitive in vitro assays to define substrate preferences and sites of nucleic-acid binding, modifying, and cleaving agents" was invented by J. Keith Joung (Winchester, Mass.), Vikram Pattanayak (Wellesley, Mass.), Karl Petri (Cambridge, Mass.), Jason Michael Gehrke (Cambridge, Mass.) and Kanae Esther Sasaki (Somerville, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are, among other things, in vitro methods of identifying double stranded DNA sequences that are cleaved by a nuclease. For example, by providing a library of defined linear dsDN...