US Patent Issued to The General Hospital, The Children's Medical Center on Oct. 27 for "Lineage inference from single-cell transcriptomes" (Massachusetts Inventors)

ALEXANDRIA, Va., Oct. 27 -- United States Patent no. 12,774,495, issued on Oct. 27, was assigned to The General Hospital Corp. and The Children's Medical Center Corp..

"Lineage inference from single-cell transcriptomes" was invented by Bradley Bernstein (Boston), Peter van Galen (Boston), Tyler Miller (Boston), Caleb Lareau (Boston) and Vijay Sankaran (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "Embodiments disclosed herein provide methods of using somatic mutations in mitochondrial genomes to retrospectively infer cell lineages in native contexts and to serve as genetic barcodes to measure clonal dynamics in complex cellular populations. Further, somatic mutations in mitochondrial DNA (mtDNA) are ...